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While animal studies consistently demonstrate beneficial effects across diverse injury models and tissue types, the absence of adequately powered, controlled human clinical trials prevents definitive conclusions about efficacy in human disease

Injections may be discussed for more body-wide effects, but the route should be clinician-led

An extended protocol might look like this: This 32-week escalation requires more total semaglutide (approximately 29.4 mg to reach maintenance) but significantly reduces the chance of side-effect-driven protocol abandonment

Individual inflammatory baseline and immune capacity likely influence response